What are the consequences of imbalance of intestinal microflora?

Heather Campbell
 min read

What are the consequences of imbalance of intestinal microflora?

What are the consequences of imbalance of intestinal microflora?The negative outcomes can vary, from mere discomfort to mood swings.

As a whole, an imbalance of intestinal microflora has a major effect on our body. It can manifest itself as allergies, weight gain, bloating and aggravate other conditions such as joint diseases and fibromyalgia and other autoimmune diseases.

An imbalance (dysbiosis) in the microbiota (intestinal flora) can lead to several disorders, some of which are totally unexpected and extremely common.

Read on to learn more about this imbalance of intestinal microflora that is seemingly harmless but has such devastating consequences…

What are the consequences of imbalance of intestinal microflora? Introduction

Dysbiosis is a factor that favors the proliferation of pathogenic germs and is often responsible for the following disturbances:

  • A loss of mucosal seal, i.e. the loss of junction of the enterocytic cells.
  • A low-grade inflammation (silent chronic inflammation) or high-grade inflammation of the intestinal mucosa that can no longer ensure its function of digestion and especially assimilation.

This junction defect is responsible for increasing intestinal intercellular permeability (intestinal hyperpermeability or intestinal intercellular hyperpermeability).

This results in the inappropriate passage of peptides or proteins from poorly digested food, or debris from bacterial microorganisms from our own microbiota.

This situation activates the intestinal immune system, which is called upon to neutralize these normally non-aggressive but which become so through incomplete digestion and unsatisfactory assimilation.

They then become substances considered foreign to the body.

The consequences of these phenomena of dysbiosis, inflammation, intercellular intestinal hyperpermeability and the activation of the intestinal immune system can manifest themselves locally or at a distance and involve one or more other organs of the body.

Local disturbances of intestinal microflora

Local disturbances can be revealed by functional digestive disorders, apparently benign, but potentially chronic until the installation of a true digestive inflammatory disease, most often if you have a high genetic vulnerability.

These are functional digestive disorders such as:

  • Organic digestive disorders (Crohn’s disease, ulcerative colitis, etc.)
  • Abdominal pain
  • Bloating
  • Digestive discomfort
  • Transit disorders (constipation, diarrhea…)

All these digestive signs, even functional ones, should not be minimized. They indicate a dysfunction and therefore a change in the digestive function.

As this function is of primary importance, all these small functional signs must be taken into account and managed.

If you do not see any improvement despite taking a probiotic and detoxifying plants, consult a doctor specialized in micronutrition.

Disturbances at a distance

They can appear in other mucous membranes (ear, vaginal, pharynx, larynx, eye, urinary, bronchial, sinus), skin tissue, joints, periarticular, etc.

And they can be expressed in the form of ear-nose-throat, urinary, bronchopulmonary or gynecological infections, but also hives, eczema, musculoskeletal pain, etc.

More severe manifestations include (aggravation of) joint diseases (rheumatoid arthritis due to an imbalance in the gut and ankylosing spondylitis), true allergies, fibromyalgia, autoimmune diseases (lupus, diabetes and multiple sclerosis), etc.

Consequences of imbalance of intestinal microflora

Disturbances may manifest as weight gain, insulin resistance and hyperglycemia.

In other words, all of the major characteristics of metabolic syndrome.

What is metabolic syndrome?

Metabolic syndrome is the result of a hereditary predisposition combined with certain lifestyle factors:

  • Lack of sunlight (vitamin D deficiency)
  • Poor nutrition
  • Tobacco
  • A chronic lack of sleep
  • Overweight
  • Sedentary lifestyle
  • Stress
  • Age

It is not a disease per se, but a set of signs that greatly increase the risk of diabetes, heart disease or stroke.

It is considered a precursor to type II diabetes, particularly marked in cases of overconsumption of sweet-tasting foods.

In addition to recognized psychosocial factors, depression can also be caused and maintained by inflammation of digestive origin.

The association of dysbiosis and intestinal inflammation

By extension, all inflammatory diseases (rheumatoid arthritis, ankylosing spondylitis, obesity, cardiovascular disease and neurodegenerative diseases) can have their origin in dysbiosis.

The combination of these two phenomena, dysbiosis and intestinal inflammation, promotes the emission of hormonal messengers.

Diabetes and obesity as a consequence

Dysbiosis and inflammation activate the nervous system of the gut as well as nerve cells in different regions of the brain and result in metabolic dysregulations such as diabetes and obesity.

Hence the major interest in screening for possible dysbiosis in all so-called civilization diseases (overweight, obesity, diabetes, metabolic syndrome, etc.).

It is important to eliminate two major infectious causes of dysbiosis before any micronutritional treatment:

  • Parasitosis, even minor ones
  • Candidiasis in order to treat them and optimize micronutritional management

What is the influence of the gut on mood disorders?

An adequate protein intake is required for a good tryptophan (amino acid) status, followed by excellent digestion and assimilation.

Any disturbance of one or more of these three elements (poor assimilation, inadequate protein portion and/or poor digestion) will be responsible for a serotonin supply deficit.

Mood disorders will be quickly discerned and more intense if tryptophan intake is insufficient.

Related post: What role do gut bacteria play in digestion? Health insights

What are the consequences of imbalance of intestinal microflora? Conclusion

From the expected (abdominal pain, bloating and transit disorders) to the unexpected (eye, nose and throat issues and aggravation of auto-immune diseases and depression).

Intestinal microflora are key to our well-being, and their imbalance should not be taken lightly.

Related postDirect and indirect functions of the bacterial flora within the human gut

About Heather Campbell

As a nutritionist, my field of specialization is science-based nutritional advice but more importantly, it is my goal to share capturing and inspiring stories, examples and solutions which can help plus-size individuals overcome their specific difficulties. Read More